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1

Function of Inhibitor of Brutons Tyrosine Kinase Isoform α (IBTKα) in Nonalcoholic Steatohepatitis links Autophagy and the Unfolded Protein Response

Willy, Jeffrey A., Young, Sara K., Mosley, Amber L., Gawrieh, Samer, Stevens, James L., Masuoka, Howard C., Wek, Ronald C.

Journal:

Journal of Biological Chemistry

Year:

2017

Language:

english

File:

PDF, 3.55 MB

english, 2017

2

Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress

Journal:

Cold Spring Harbor Perspectives in Biology

Year:

2018

Language:

english

File:

PDF, 899 KB

english, 2018

3

Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver

Nikonorova, Inna A., Mirek, Emily T., Signore, Christina C., Goudie, Michael P., Wek, Ronald C., Anthony, Tracy G.

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 2.93 MB

english, 2018

4

Inhibitory sequences in the N-terminus of the double-stranded-RNA-dependent protein kinase, PKR, are important for regulating phosphorylation of eukaryotic initiation factor 2α (eIF2α)

Krishna M. Vattem, Kirk A. Staschke, Shuhao Zhu, Ronald C. Wek

Journal:

Year:

2001

Language:

english

File:

PDF, 609 KB

english, 2001

5

Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR : Role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2)

Krishna M. Vattem, Kirk A. Staschke, Ronald C. Wek

Journal:

Year:

2001

Language:

english

File:

PDF, 801 KB

english, 2001

6

Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway inSaccharomyces cerevisiae

John M Zaborske, Xiaochen Wu, Ronald C Wek, Tao Pan

Journal:

BMC Biochemistry

Year:

2010

Language:

english

File:

PDF, 1.17 MB

english, 2010

7

Stress response pathways in protozoan parasites

Nathalie Vonlaufen, Stefan M. Kanzok, Ronald C. Wek, William J. Sullivan Jr

Journal:

Cellular Microbiology

Year:

2008

Language:

english

File:

PDF, 398 KB

english, 2008

8

How do tumours adapt to nutrient stress?

Wek, Ronald C, Staschke, Kirk A

Journal:

The EMBO Journal

Year:

2010

Language:

english

File:

PDF, 210 KB

english, 2010

9

Obesity: stressing about unfolded proteins

Wek, Ronald C, Anthony, Tracy G

Journal:

Nature Medicine

Year:

2010

Language:

english

File:

PDF, 359 KB

english, 2010

10

Obesity: stressing about unfolded proteins

Wek, Ronald C, Anthony, Tracy G

Journal:

Nature Medicine

Year:

2010

Language:

english

File:

PDF, 68 KB

english, 2010

11

elF-2 kinases: regulators of general and gene-specific translation initiation

Journal:

Trends in Biochemical Sciences

Year:

1994

Language:

english

File:

PDF, 708 KB

english, 1994

12

The Double-Stranded RNA-Activated Protein Kinase PKR Is Dispensable for Regulation of Translation Initiation in Response to either Calcium Mobilization from the Endoplasmic Reticulum or Essential Amino Acid Starvation

Scot R. Kimball, Michael J. Clemens, Vivienne J. Tilleray, Ronald C. Wek, Rick L. Horetsky, Leonard S. Jefferson

Journal:

Biochemical and Biophysical Research Communications

Year:

2001

Language:

english

File:

PDF, 267 KB

english, 2001

13

Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility

Mimi A. Trinh, Hanoch Kaphzan, Ronald C. Wek, Philippe Pierre, Douglas R. Cavener, Eric Klann

Journal:

Year:

2012

Language:

english

File:

PDF, 1.58 MB

english, 2012

14

EXtENDINg β cell survival by UPRegulating ATF4 translation

Ronald C. Wek, Tracy G. Anthony

Journal:

Cell Metabolism

Year:

2006

Language:

english

File:

PDF, 187 KB

english, 2006

15

Beta Testing the Antioxidant Function of eIF2α Phosphorylation in Diabetes Prevention

Ronald C. Wek, Tracy G. Anthony

Journal:

Cell Metabolism

Year:

2009

Language:

english

File:

PDF, 223 KB

english, 2009

16

The Roles of Stress-Activated Sty1 and Gcn2 Kinases and of the Protooncoprotein Homologue Int6/eIF3e in Responses to Endogenous Oxidative Stress during Histidine Starvation

Naoki Nemoto, Tsuyoshi Udagawa, Takahiro Ohira, Li Jiang, Kouji Hirota, Caroline R.M. Wilkinson, Jürg Bähler, Nic Jones, Kunihiro Ohta, Ronald C. Wek, Katsura Asano

Journal:

Journal of Molecular Biology

Year:

2010

Language:

english

File:

PDF, 1.85 MB

english, 2010

17

The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells

Jennifer N. Gass, Hao-Yuan Jiang, Ronald C. Wek, Joseph W. Brewer

Journal:

Molecular Immunology

Year:

2008

Language:

english

File:

PDF, 735 KB

english, 2008

18

Translational Control and the Unfolded Protein Response

Wek, Ronald C., Cavener, Douglas R.

Journal:

Antioxidants & Redox Signaling

Year:

2007

Language:

english

File:

PDF, 438 KB

english, 2007

19

Transcriptional activation at adjacent operators in the divergent-overlapping ilvY and ilvC promoters of Escherichia coli

Ronald C. Wek, G.Wesley Hatfield

Journal:

Journal of Molecular Biology

Year:

1988

Language:

english

File:

PDF, 9.24 MB

english, 1988

20

Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

Thomas E. Dever, Lan Feng, Ronald C. Wek, A.Mark Cigan, Thomas F. Donahue, Alan G. Hinnebusch

Journal:

Year:

1992

Language:

english

File:

PDF, 1.89 MB

english, 1992

21

TXNIP Switches Tracks toward a Terminal UPR

Tracy G. Anthony, Ronald C. Wek

Journal:

Cell Metabolism

Year:

2012

Language:

english

File:

PDF, 474 KB

english, 2012

22

GCN2-like eIF2α kinase manages the amino acid starvation response in Toxoplasma gondii

Konrad, Christian, Wek, Ronald C., Sullivan, William J.

Journal:

International Journal for Parasitology

Year:

2014

Language:

english

File:

PDF, 616 KB

english, 2014

23

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2

Cambiaghi, Tavane D., Pereira, Catia M., Shanmugam, Renuka, Bolech, Michael, Wek, Ronald C., Sattlegger, Evelyn, Castilho, Beatriz A.

Journal:

Biochemical and Biophysical Research Communications

Year:

2014

Language:

english

File:

PDF, 1.23 MB

english, 2014

24

Juxtaposition of Domains Homologous to Protein Kinases and Histidyl-tRNA Synthetases in GCN2 Protein Suggests a Mechanism for Coupling GCN4 Expression to Amino Acid Availability

Ronald C. Wek, Belinda M. Jackson and Alan G. Hinnebusch

Journal:

Proceedings of the National Academy of Sciences

Year:

1989

Language:

english

File:

PDF, 1.54 MB

english, 1989

25

Translation control is critical during acute and chronic stages of toxoplasmosis infection

Joyce, Bradley R, Konrad, Christian, Wek, Ronald C, Sullivan Jr, William J

Journal:

Expert Review of Anti-infective Therapy

Year:

2011

Language:

english

File:

PDF, 258 KB

english, 2011

26

GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment

Wilson, Gabriel J., Lennox, Brittany A., She, Pengxiang, Mirek, Emily T., Al Baghdadi, Rana J. T., Fusakio, Michael E., Dixon, Joseph L., Henderson, Gregory C., Wek, Ronald C., Anthony, Tracy G.

Journal:

AJP Endocrinology and Metabolism

Year:

2015

Language:

english

File:

PDF, 1.51 MB

english, 2015

27

DNA Methyltransferase Protein Synthesis Is Reduced in CXXC Finger Protein 1–Deficient Embryonic Stem Cells

Butler, Jill S., Palam, Lakshmi R., Tate, Courtney M., Sanford, Jeremy R., Wek, Ronald C., Skalnik, David G.

Journal:

DNA and Cell Biology

Year:

2009

Language:

english

File:

PDF, 11.79 MB

english, 2009

28

Phosphorylation of the α subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus

Carnevalli, Larissa S., Pereira, Catia M., Jaqueta, Carolina B., Alves, Viviane S., Paiva, Vanessa N., Vattem, Krishna M., Wek, Ronald C., Mello, Luiz Eugênio A. M., Castilho, Beatriz A.

Journal:

Biochemical Journal

Year:

2006

Language:

english

File:

PDF, 440 KB

english, 2006

29

Crystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and Mammals

He, Hongzhen, Singh, Isha, Wek, Sheree A., Dey, Souvik, Baird, Thomas D., Wek, Ronald C., Georgiadis, Millie M.

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 3.27 MB

english, 2014

30

The complete nucteotide sequence of tbe ilvGMEDA operon of Escherichia coli K-12

Lawther, Robert P., Wek, Ronald C., Lopes, John M., Pereira, Ruth, Taillon, Bruce E., Hatfield, G. Wesley

Journal:

Nucleic Acids Research

Year:

1988

File:

PDF, 21 KB

1988

31

Int6/eIF3e Promotes General Translation and Atf1 Abundance to Modulate Sty1 MAPK-dependent Stress Response in Fission Yeast

Udagawa, Tsuyoshi, Nemoto, Naoki, Wilkinson, Caroline R. M., Narashimhan, Jana, Jiang, Li, Watt, Stephen, Zook, Aaron, Jones, Nic, Wek, Ronald C., Bähler, Jürg, Asano, Katsura

Journal:

Journal of Biological Chemistry

Year:

2008

Language:

english

File:

PDF, 1.18 MB

english, 2008

32

Translational Repression Protects Human Keratinocytes from UVB-Induced Apoptosis through a Discordant eIF2 Kinase Stress Response

Collier, Ann E, Wek, Ronald C, F Spandau, Dan

Journal:

The Journal of Investigative Dermatology

Year:

2015

Language:

english

File:

PDF, 4.07 MB

english, 2015

33

The complete nucleotide sequence of the ilvGMEDA operon of Escherichia coli K-12

Lawther, Robert P., Wek, Ronald C., Lopes, John M., Pereira, Ruth, Taillon, Bruce E., Hatfield, G. Wesley

Journal:

Nucleic Acids Research

Year:

1987

Language:

english

File:

PDF, 33 KB

english, 1987

34

The complete nucleotide sequence of the ilvGMEDA Operon of Escherichia Coli K-12

Lawther, Robert P., Wek, Ronald C., Lopes, John M., Perira, Ruth, Taillon, Bruce E., Wesley, G.

Journal:

Nucleic Acids Research

Year:

1987

Language:

english

File:

PDF, 998 KB

english, 1987

35

Examination of the internal promoter, P E , in the ilvGMEDA operon of E. coli K-12

Wek, Ronald C., Hatfield, G.Wesley

Journal:

Nucleic Acids Research

Year:

1986

Language:

english

File:

PDF, 1.39 MB

english, 1986

36

The nucleotide sequence of the ilvBN operon of Escherichia coli : sequence homologies of the acetohydroxy acid synthase isozymes

Wek, Ronald C., Hauser, Craig A., Hatfield, G. Wesley

Journal:

Nucleic Acids Research

Year:

1985

Language:

english

File:

PDF, 1.20 MB

english, 1985

37

Guanabenz repurposed as an anti-parasitic with activity against acute and latent toxoplasmosis

Benmerzouga, Imaan, Checkley, Lisa A., Ferdig, Michael T., Arrizabalaga, Gustavo, Wek, Ronald C., Sullivan, William J.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2015

Language:

english

File:

PDF, 4.85 MB

english, 2015

38

Ribosome Reinitiation Directs Gene-Specific Translation and Regulates the Integrated Stress Response

Young, Sara K., Willy, Jeffrey A., Wu, Cheng, Sachs, Matthew S., Wek, Ronald C.

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 3.68 MB

english, 2015

39

Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control

Shi, Yuguang, Vattem, Krishna M., Sood, Ruchira, An, Jie, Liang, Jingdong, Stramm, Lawrence, Wek, Ronald C.

Journal:

Molecular and Cellular Biology

Year:

1998

Language:

english

File:

PDF, 1.13 MB

english, 1998

40

Phosphorylation of eukaryotic initiation factor-2α promotes the extracellular survival of obligate intracellular parasite Toxoplasma gondii

Bradley R. Joyce, Sherry F. Queener, Ronald C. Wek and William J. Sullivan, Jr.

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.48 MB

english, 2010

41

Ribosome Elongation Stall Directs Gene-specific Translation in the Integrated Stress Response

Young, Sara K., Palam, Lakshmi Reddy, Wu, Cheng, Sachs, Matthew S., Wek, Ronald C.

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 2.11 MB

english, 2016

42

Translation Regulation of the Glutamyl-prolyl-tRNA Synthetase Gene EPRS through Bypass of Upstream Open Reading Frames with Noncanonical Initiation Codons

Young, Sara K., Baird, Thomas D., Wek, Ronald C.

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 1.96 MB

english, 2016

43

GCN2 phosphorylation of eIF2α activates NF-κB in response to UV irradiation

JIANG, Hao-Yuan, WEK, Ronald C.

Journal:

Biochemical Journal

Year:

2005

Language:

english

File:

PDF, 592 KB

english, 2005

44

General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice

Phillipson-Weiner, Lindsey, Mirek, Emily T., Wang, Yongping, McAuliffe, W. Geoffrey, Wek, Ronald C., Anthony, Tracy G.

Journal:

AJP Gastrointestinal and Liver Physiology

Year:

2016

Language:

english

File:

PDF, 1.35 MB

english, 2016

45

Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression

Young, Sara K., Shao, Yu, Bidwell, Joseph P., Wek, Ronald C.

Journal:

Journal of Biological Chemistry

Year:

2016

Language:

english

File:

PDF, 1.28 MB

english, 2016

46

Pancreatic eukaryotic initiation factor-2α kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

SOOD, Ruchira, PORTER, Amy C., MA, Kun, QUILLIAM, Lawrence A., WEK, Ronald C.

Journal:

Biochemical Journal

Year:

2000

Language:

english

File:

PDF, 449 KB

english, 2000

47

Parasite-specific eIF2 (eukaryotic initiation factor-2) kinase required for stress-induced translation control

SULLIVAN, William J., NARASIMHAN, Jana, BHATTI, Micah M., WEK, Ronald C.

Journal:

Biochemical Journal

Year:

2004

Language:

english

File:

PDF, 871 KB

english, 2004

48

Site-directed mutagenesis of the active site of diacylglycerol kinase α: calcium and phosphatidylserine stimulate enzyme activity via distinct mechanisms

ABE, Takahiro, LU, Xiaolan, JIANG, Ying, BOCCONE, Clark E., QIAN, Shaomin, VATTEM, Krishna M., WEK, Ronald C., WALSH, James P.

Journal:

Biochemical Journal

Year:

2003

Language:

english

File:

PDF, 445 KB

english, 2003

49

Impaired growth and neurological abnormalities in branched-chain α-keto acid dehydrogenase kinase-deficient mice

Joshi, Mandar A., Jeoung, Nam Ho, Obayashi, Mariko, Hattab, Eyas M., Brocken, Eric G., Liechty, Edward A., Kubek, Michael J., Vattem, Krishna M., Wek, Ronald C., Harris, Robert A.

Journal:

Biochemical Journal

Year:

2006

Language:

english

File:

PDF, 377 KB

english, 2006

50

A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation

Lopez, Alex B., Wang, Chuanping, Huang, Charlie C., Yaman, Ibrahim, Li, Yi, Chakravarty, Kaushik, Johnson, Peter F., Chiang, Cheng-Ming, Snider, Martin D., Wek, Ronald C., Hatzoglou, Maria

Journal:

Biochemical Journal

Year:

2007

Language:

english

File:

PDF, 516 KB

english, 2007